Zantac Case Criteria

At least 1 year of Zantac (ranitidine) usage prior to cancer diagnosis.

Minimum of 300 mg/week during 1-year period of usage.

No more than 10 years since last Zantac (ranitidine) usage prior to cancer diagnosis.

At least six months of Zantac (ranitidine) usage during pregnancy.

Minimum of 300 mg/week during 6 months of pregnancy.

No more than 5 years after birth for diagnosis of cancer.

At least 1 year of Zantac (ranitidine) usage prior to cancer diagnosis.

Minimum of 150 mg/week during 1-year period of usage

No more than 1 year since last Zantac (ranitidine) usage prior to cancer diagnosis.

No smoking 25 years prior to diagnosis.

No frequent ingestion of very hot liquids (common in certain near-eastern cultures and in China and Japan).

No abdomen radiation exposure (i.e., for medical treatment, not X-rays, or other diagnostic scans) prior to diagnosis.

No Barrett’s esophagus prior to Zantac use.

No smoking in excess of 10 cigarettes per day. Heavier smokers are ok provided they quit at least 10 years prior to diagnosis.

No immediate family member with renal cancer (unless family member was also exposed to Zantac).

No obesity (over 30 BMI) 5 years prior to diagnosis.

No hypertension prior to diagnosis,

No Hippel-Lindau disease.

No Britt-Hogg-Dube Syndrome.

No tuberous sclerosis complex.

No occupational exposure to cadmium.

No Type II diabetes.

No Hepatitis B or C.

No heavy drinkers (14 or more drinks per week). Ok if heavy drinking ceased within 10 years prior to diagnosis.

No hemochromatosis.

No Wilson’s disease.

No non-alcoholic fatty liver disease.

No smoking 25 years prior to diagnosis.

No occupational radon gas exposure.

No occupational asbestos exposure.

No occupational arsenic exposure,

No occupational chromium exposure.

No parents with lung cancer (who were non-smokers and who were not exposed to Zantac).

• No parents with lung cancer (who were non-smokers and who were not exposed to Zantac).

No familial history of prostate cancer (unless family member was also exposed to Zantac).

No BRCA 1 or BRCA 2 mutation (if known).

No smoking 25 years prior to diagnosis.

No family history of stomach cancer (unless family member was also exposed to Zantac).

No H-pylori infection prior to Zantac use.

No history of anemia.

No undescended testis.

No Klinefelter syndrome.

No undescended testis.

No Klinefelter syndrome.

No prenatal smoking.

No prenatal maternal smoking.

No prenatal maternal exposure to radiation or chemotherapy.

No history of same cancer in mother or father.